Sperm Syringe: 3D Sorting Platform for Assisted Reproduction

Selection of high-quality sperm is crucial to assisted reproduction. However, conventional clinical methods for selection are manual and prone operator errors. This article presents ‘sperm syringe', a scalable technology that mimics the highly parallelized 3D process in vivo via network 560 microchannels select sperm. Sperm syringe retrieves more than 41% healthy from initial sample under 15 min, providing sufficient volume (≈500 µL) number (1,600,000) fertility treatments. Experiments with bull human indicate 65% improvement selected morphology DNA integrity, considerably outperforming current best practices. approach enables subpopulation an oligozoospermia integrity below reference value fertility. The fabrication method device also simple scalable, representing commercially viable translation adoption. provides promising opportunity clinics use less invasive reproductive technologies (ARTs) over intracytoplasmic injection, thus reducing associated workload optimizing long-term health outcomes ART-conceived children.